Stability Research Cluster
Curated resources focused on degradation science, practical storage decisions, and potency forecasting.
Complete Storage Guide
Protocol-level temperature and handling standards.
Storage Guidelines Checklist
Short operational checklist for refrigerated workflows and discard decisions.
Temperature Impact Research
Why temperature changes drive non-linear decay behavior.
Freeze-Thaw Damage Analysis
Mechanistic risks for freeze-sensitive peptides.
Peptide Oxidation Deep Dive
Oxidative pathways that reduce peptide activity.
Storage Temperature FAQ
Short answers about refrigeration, room temperature exposure, and freezer risk.
Potency Calculator
Estimate remaining potency over time from storage inputs.
Scientific Framework
All stability estimates on this site are based on the following peer-reviewed sources and regulatory frameworks:
- ICH Q1A(R2) — Stability Testing of New Drug Substances and Products (EMA/FDA) — Temperature-driven degradation framework; first-order kinetics standard
- ICH Q5C — Quality of Biotechnological Products: Stability Testing — Biological/peptide product stability guidelines
- Waterman & Adami — Accelerated aging: prediction of chemical stability of pharmaceuticals (PMID 15778049, Int J Pharm 2005) — Arrhenius-based temperature acceleration model
- Wang & Roberts — Non-Arrhenius Protein Aggregation (PMID 23615748, AAPS J 2013) — Non-linear aggregation behavior; caveat on Q10 = 2 rule
- Mazur et al. — Freeze-thaw characterization for protein therapeutics (PMID 34059716, Sci Rep 2021) — Freeze-induced aggregation mechanisms
- Hauptmann et al. — Freezing-induced aggregation and pH shift (PMID 32335158, Int J Pharm 2020)
- Label-backed data: Ozempic (semaglutide) FDA Label 2025 | Mounjaro (tirzepatide) FDA Label 2026
Peptide-specific decay rates are model estimates [Model Estimate — PeptideClock] calibrated from available pharmacological data. High-confidence rates (Semaglutide, Liraglutide) are derived from FDA label stability windows. Medium/low confidence rates are conservative extrapolations — not direct experimental shelf-life assays.