Complete Guide to Peptide Storage
Storage control is one of the strongest predictors of usable potency over time. This guide provides protocol-level handling standards you can apply immediately.
Temperature Ranges by Stability Class
| Class | Fridge (2-8°C) | Room (~25°C) | Freezer (-20°C) |
|---|---|---|---|
| Robust | 30-60+ days | 7-14 days | Long-term powder storage preferred |
| Standard | 14-30 days | 3-7 days | Peptide-dependent |
| Fragile | 7-14 days | 1-3 days | High caution if reconstituted |
| Highly Volatile | 3-10 days | Often rapid decline | Strict peptide-specific control required |
Stability windows above are [Model Estimates — PeptideClock] based on peptide class decay rates calibrated to ICH Q1A(R2) principles. Individual peptide pages provide confidence levels. Label-backed window: Semaglutide 56 days after first use (Ozempic FDA label).
Storage Checklist
- Use consistent refrigeration and avoid door zones
- Protect vials from light and repeated thermal cycling
- Label peptide name, solvent, concentration, and reconstitution date
- Track inventory using FIFO rotation
- Inspect visually before each use
Common Failure Patterns
- Frequent out-of-fridge exposure during handling
- Unlabeled vials and date confusion
- Mixing protocols with inconsistent solvent standards
- Freeze-thaw cycles on freeze-sensitive compounds
Evidence Basis
- ICH Q1A(R2) — Stability Testing Guidelines (EMA)
- ICH Q5C — Biological Product Stability (ICH)
- Mazur et al. — Freeze-thaw protein aggregation (PMID 34059716)
- Waterman & Adami — Arrhenius pharmaceutical stability modeling (PMID 15778049)
- Ozempic (semaglutide) FDA Label 2025 — label-backed 56-day in-use stability window